UK Healthcare Professionals only
Weekly newsletter (optional)
Join the weekly newsletter to receive curated evidence that matters.
This week's key publications in 50 words
Each week our clinical team selects the most important new publications and distils each one into 50 words, so you get the signal without the noise.
FreeDM2 randomised 303 UK adults with basal-insulin-treated type 2 diabetes to real-time CGM versus fingerstick monitoring. At 32 weeks, CGM was associated with a 5 mmol/mol greater HbA1c reduction (62 vs 67 mmol/mol) and around 10% more time in range, with no increase in hypoglycaemia. Funded by Abbott.
Read sourceIn 768 Spanish primary care patients with uncomplicated lower UTI (dysuria, urgency, frequency, or suprapubic tenderness plus positive dipstick), nitrofurantoin 100mg tds for 5 days, pivmecillinam 400mg tds for 3 days, single-dose fosfomycin, and two-dose fosfomycin were compared. Authors concluded nitrofurantoin most effective, single-dose fosfomycin least effective. Open-label design.
Read source26 interviews and 4 focus groups across 20 UK practices. Awareness of CKD diagnostic criteria was high, but awareness of risk stratification tools was low. Time pressures and lack of incentivisation were identified as key barriers, alongside concerns about patient anxiety and over-medicalisation. Authors suggest education, pathways and automation as improvements.
Read sourceCPRD case-control of 9,662 UK MS cases and 56,455 matched controls. Seven prescription categories (including LUTS, UTI, migraine, GI, antidepressants, ED) were associated with subsequent MS, with odds ratios 3–7 times higher in the 2 years pre-diagnosis. Inflection points ranged 9–72 months pre-diagnosis, with wide confidence intervals.
Read sourceORCHID retrospective cohort: 82,285 of 635,698 eligible patients aged ≥65 received an SMR during April 2020–September 2022. SMRs were associated with both new prescriptions and cessation of ACE inhibitors, statins and antidepressants. Between 12.5% and 40% of potentially inappropriate drug combinations were corrected within three months.
Read sourceQualitative study: 35 GPs, 3 other clinicians and 3 administrators across 31 practices in Southern England. Interim non-cancer diagnoses were reported to occur with non-specific symptoms and remote consultations. Participants described using safety-netting and an informal "three strikes and you're in" rule, and valued colleagues offering fresh perspectives.
Read sourceNever miss an edition
MicroMedicine Central is published weekly as part of the Medicine Central newsletter, free for registered UK healthcare professionals.
Join freeWe use cookies to improve your experience and analyse site usage. Strictly necessary cookies are always active. By clicking Accept All, you consent to analytics and performance cookies. Cookie Policy · Privacy Policy
